論文 - 詳細
| RRC ID | 82980 |
|---|---|
| 著者 | Kawase K, Nakamura Y, Wolbeck L, Takemura S, Zaitsu K, Ando T, Jinnou H, Sawada M, Nakajima C, Rydbirk R, Gokenya S, Ito A, Fujiyama H, Saito A, Iguchi A, Kratimenos P, Ishibashi N, Gallo V, Iwata O, Saitoh S, Khodosevich K, Sawamoto K. |
| タイトル | Significance of birth in the maintenance of quiescent neural stem cells. |
| ジャーナル | Sci Adv |
| Abstract |
Birth is one of the most important life events for animals. However, its significance in the developmental process is not fully understood. Here, we found that birth-induced alteration of glutamine metabolism in radial glia (RG), the embryonic neural stem cells (NSCs), is required for the acquisition of quiescence and long-term maintenance of postnatal NSCs. Preterm birth impairs this cellular process, leading to transient hyperactivation of RG. Consequently, in the postnatal brain, the NSC pool is depleted and neurogenesis is decreased. We also found that the maintenance of quiescent RG after preterm birth improves postnatal neurogenesis. This study demonstrates the significance of birth in the maintenance of quiescent NSCs. |
| 巻・号 | 11(4) |
| ページ | eadn6377 |
| 公開日 | 2025-1-24 |
| DOI | 10.1126/sciadv.adn6377 |
| PMID | 39841848 |
| PMC | PMC11753423 |
| MeSH | Animals Animals, Newborn Brain / cytology Brain / metabolism Cell Proliferation Ependymoglial Cells / cytology Ependymoglial Cells / metabolism Female Glutamine / metabolism Mice Neural Stem Cells* / cytology Neural Stem Cells* / metabolism Neurogenesis* Parturition |
| IF | 13.117 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 45 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pCMV-VSV-G-RSV-Rev (RDB04393) pCAG-HIVgp (RDB04394) |