論文 - 詳細
| RRC ID | 83316 |
|---|---|
| 著者 | Ishikawa H, Kuno Y, Yokoo T, Nagashima R, Takaki T, Sasaki H, Kohda C, Iyoda M. |
| タイトル | In vitro investigation of the effects of Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 exopolysaccharides on tight junction damage caused by influenza virus infection. |
| ジャーナル | Lett Appl Microbiol |
| Abstract |
It is a problem that influenza virus infection increases susceptibility to secondary bacterial infection in lungs leading to lethal pneumonia. We previously reported that exopolysaccharides (EPS) derived from Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 (OLL1073R-1) could prevent against influenza virus infection followed by secondary bacterial infection in vitro. Therefore, the present study assessed whether EPS derived OLL1073R-1 protects the alveolar epithelial barrier disfunction caused by influenza virus infection. After A549 cells treated with EPS or without EPS were infected influenza virus A/Puerto Rico/8/34 (IFV) for 12 h, the levels of tight junction genes expression and inflammatory genes expression were measured by reverse transcription polymerase chain reaction. As results, EPS treatment could protect against low-titer IFV infection, but not high-titer IFV infection, followed by suppression of the increased expression of inflammatory cytokine gene levels and recovery of the decrease in the expression level of ZO-1 gene that was caused by low-titer IFV infection, leading to an improvement trend in the barrier function. Our findings showed that EPS derived from OLL1073R-1 could inhibit low-titer IFV infection leading to maintenance of the epithelial barrier function through the suppression of inflammatory cytokine genes expression. |
| 巻・号 | 77(4) |
| 公開日 | 2024-4-8 |
| DOI | 10.1093/lambio/ovae029 |
| PII | 7634354 |
| PMID | 38521981 |
| MeSH | Bacterial Infections* Cytokines / genetics Cytokines / metabolism Humans Influenza, Human* Lactobacillus delbrueckii* / genetics Lactobacillus delbrueckii* / metabolism Orthomyxoviridae* Tight Junctions |
| IF | 2.173 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | A549 |