| RRC ID |
83333
|
| Author |
Chen YY, Liu YF, Liu YD, Deng XH, Zhou J.
|
| Title |
IRF7 suppresses hematopoietic regeneration under stress via CXCR4.
|
| Journal |
Stem Cells
|
| Abstract |
Hematopoietic stem cells (HSCs) maintain quiescence under steady state; however, they are compelled to proliferate and expand to replenish the blood system under stress. The molecular basis underlying stress hematopoiesis remains to be fully understood. In this study, we reported that IRF7 represents an important regulator of stress hematopoiesis. Interferon regulatory factor 7 (IRF7) was dispensable for normal hematopoiesis, whereas its deficiency significantly enhanced hematopoietic stem and progenitor cells (HSPCs) regeneration and improved long-term repopulation of HSCs under stress. Mechanistic studies showed that CXCR4 was identified as a downstream target of IRF7. Overexpression of CXCR4 abrogated the enhanced proliferation and regeneration of IRF7-deficient HSPCs under stress. Similar results were obtained in HSCs from human umbilical cord blood. These observations demonstrated that IRF7 plays an important role in hematopoietic regeneration under stress.
|
| Volume |
39(2)
|
| Pages |
183-195
|
| Published |
2021-2-1
|
| DOI |
10.1002/stem.3308
|
| PMID |
33252829
|
| MeSH |
Animals
Cells, Cultured
Cord Blood Stem Cell Transplantation / methods*
Fetal Blood / metabolism
Fetal Blood / transplantation
Hematopoiesis / physiology*
Humans
Interferon Regulatory Factor-7 / antagonists & inhibitors
Interferon Regulatory Factor-7 / genetics
Interferon Regulatory Factor-7 / metabolism*
Mice
Mice, Inbred C57BL
Mice, Knockout
Oxidative Stress / physiology*
Receptors, CXCR4 / genetics
Receptors, CXCR4 / metabolism*
|
| IF |
6.022
|
| Resource |
| Mice |
RBRC01420 |
