論文 - 詳細
| RRC ID | 83340 |
|---|---|
| 著者 | Yoshinari Y, Nishimura T, Yoshii T, Kondo S, Tanimoto H, Kobayashi T, Matsuyama M, Niwa R. |
| タイトル | A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster. |
| ジャーナル | Nat Commun |
| Abstract |
Protein is essential for all living organisms; however, excessive protein intake can have adverse effects, such as hyperammonemia. Although mechanisms responding to protein deficiency are well-studied, there is a significant gap in our understanding of how organisms adaptively suppress excessive protein intake. In the present study, utilizing the fruit fly, Drosophila melanogaster, we discover that the peptide hormone CCHamide1 (CCHa1), secreted by enteroendocrine cells in response to a high-protein diet (HPD), is vital for suppressing overconsumption of protein. Gut-derived CCHa1 is received by a small subset of enteric neurons that produce short neuropeptide F, thereby modulating protein-specific satiety. Importantly, impairment of the CCHa1-mediated gut-enteric neuronal axis results in ammonia accumulation and a shortened lifespan under HPD conditions. Collectively, our findings unravel the crosstalk of gut hormone and neuronal pathways that orchestrate physiological responses to prevent and adapt to dietary protein overload. |
| 巻・号 | 15(1) |
| ページ | 10819 |
| 公開日 | 2024-12-30 |
| DOI | 10.1038/s41467-024-55050-y |
| PII | 10.1038/s41467-024-55050-y |
| PMID | 39737959 |
| PMC | PMC11685984 |
| MeSH | Animals Behavior, Animal / drug effects Diet, High-Protein* Dietary Proteins / administration & dosage Dietary Proteins / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* Enteroendocrine Cells / metabolism Female Gastrointestinal Hormones / metabolism Longevity Male Neurons / metabolism Neuropeptides / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 32 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#113901 sNPF-GAL4 |