論文 - 詳細
| RRC ID | 83693 |
|---|---|
| 著者 | Nguyen QD, Fujii K, Ishibashi K, Hashiba H, Ohtsubo W, Kitazawa H, Tanimoto H, Fuse N, Kurata S. |
| タイトル | Regulation of Gut Starvation Responses Through Drosophila NP3253 Neurons. |
| ジャーナル | Genes Cells |
| Abstract |
The "gut-brain axis," a bidirectional communication system between the gastrointestinal tract and the central nervous system, plays a crucial role in regulating complex physiological functions in response to nutrients, pathogens, and microbiota. However, the cellular and molecular mechanisms governing this regulation remain poorly understood. Using Drosophila melanogaster as a model organism, we previously identified NP3253 neurons, located in both the brain and gut, as key contributors to gut homeostasis during oral bacterial infection. Here, we found a novel role of NP3253 neurons in regulating starvation resistance. We observed that a subset of NP3253 neurons in the gut were activated during starvation. To investigate downstream effect, we conducted RNA-Seq analysis on the gut of adult flies with genetically silenced NP3253 neurons, comparing gene expression under starved and fed conditions. This analysis identified 26 genes differentially expressed in response to both starvation and NP3253 neuronal activity. Among these, CG12643, encoding an uncharacterized short peptide, was found to be essential for starvation resistance in the gut. Our findings demonstrate that NP3253 neurons modulate the gut gene expression in response to starvation, thereby supporting physiological adaptation to environmental stressors. |
| 巻・号 | 30(2) |
| ページ | e70005 |
| 公開日 | 2025-3-1 |
| DOI | 10.1111/gtc.70005 |
| PMID | 39904737 |
| MeSH | Animals Brain / metabolism Brain-Gut Axis Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* / metabolism Gastrointestinal Tract / metabolism Neurons* / metabolism Starvation* / metabolism |
| IF | 1.655 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.7 |
| リソース情報 | |
| ショウジョウバエ | DGRC#113183 DGRC#112001 |