論文 - 詳細
| RRC ID | 83721 |
|---|---|
| 著者 | Minowa T, Murata K, Mizue Y, Murai A, Nakatsugawa M, Sasaki K, Tokita S, Kubo T, Kanaseki T, Tsukahara T, Handa T, Sato S, Horimoto K, Kato J, Hida T, Hirohashi Y, Uhara H, Torigoe T. |
| タイトル | Single-cell profiling of acral melanoma infiltrating lymphocytes reveals a suppressive tumor microenvironment. |
| ジャーナル | Sci Transl Med |
| Abstract |
Acral lentiginous melanoma (ALM) is the most common melanoma subtype in non-Caucasians. Despite advances in cancer immunotherapy, current immune checkpoint inhibitors remain unsatisfactory for ALM. Hence, we conducted comprehensive immune profiling using single-cell phenotyping with reactivity screening of the T cell receptors of tumor-infiltrating T lymphocytes (TILs) in ALM. Compared with cutaneous melanoma, ALM showed a lower frequency of tumor-reactive CD8 clusters and an enrichment of regulatory T cells with direct tumor recognition ability, suggesting a suppressive immune microenvironment in ALM. Tumor-reactive CD8 TILs showed heterogeneous expression of coinhibitory molecules, including KLRC1 (NKG2A), in subpopulations with therapeutic implications. Overall, our study provides a foundation for enhancing the efficacy of immunotherapy in ALM. |
| 巻・号 | 16(776) |
| ページ | eadk8832 |
| 公開日 | 2024-12-4 |
| DOI | 10.1126/scitranslmed.adk8832 |
| PMID | 39630887 |
| MeSH | CD8-Positive T-Lymphocytes / immunology Female Humans Lymphocytes, Tumor-Infiltrating* / immunology Lymphocytes, Tumor-Infiltrating* / metabolism Male Melanoma* / immunology Melanoma* / pathology Middle Aged Single-Cell Analysis* Skin Neoplasms / immunology Skin Neoplasms / pathology Tumor Microenvironment* / immunology |
| IF | 16.304 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | HLA genes |