論文 - 詳細
| RRC ID | 83739 |
|---|---|
| 著者 | Jeong J, Kwon K, Geisseova TK, Lee J, Kwon T, Lim C. |
| タイトル | Drosulfakinin signaling encodes early-life memory for adaptive social plasticity. |
| ジャーナル | Elife |
| Abstract |
Drosophila establishes social clusters in groups, yet the underlying principles remain poorly understood. Here, we performed a systemic analysis of social network behavior (SNB) that quantifies individual social distance (SD) in a group over time. The SNB assessment in 175 inbred strains from the Drosophila Genetics Reference Panel showed a tight association of short SD with long developmental time, low food intake, and hypoactivity. The developmental inferiority in short-SD individuals was compensated by their group culturing. By contrast, developmental isolation silenced the beneficial effects of social interactions in adults and blunted the plasticity of SNB under physiological challenges. Transcriptome analyses revealed genetic diversity for SD traits, whereas social isolation reprogrammed select genetic pathways, regardless of SD phenotypes. In particular, social deprivation suppressed the expression of the neuropeptide Drosulfakinin (Dsk) in three pairs of adult brain neurons. Male-specific DSK signaling to cholecystokinin-like receptor 17D1 mediated the SNB plasticity. In fact, transgenic manipulations of the DSK neuron activity were sufficient to imitate the state of social experience. Given the functional conservation of mammalian Dsk homologs, we propose that animals may have evolved a dedicated neural mechanism to encode early-life experience and transform group properties adaptively. |
| 巻・号 | 13 |
| 公開日 | 2024-12-18 |
| DOI | 10.7554/eLife.103973 |
| PII | 103973 |
| PMID | 39692597 |
| PMC | PMC11706606 |
| MeSH | Animals Behavior, Animal / physiology Brain / metabolism Brain / physiology Drosophila / genetics Drosophila / physiology Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / physiology Female Male Neurons / metabolism Neurons / physiology Neuropeptides / genetics Neuropeptides / metabolism Oligopeptides / genetics Oligopeptides / metabolism Signal Transduction* Social Behavior |
| IF | 7.08 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#119026 DGRC#119027 DGRC#119029 DGRC#119030 DGRC#108362 DGRC#119155 |