Reference - Detail
| RRC ID | 83975 |
|---|---|
| Author | Wu Z, Cardona EA, Pierce JT. |
| Title | Non-apoptotic role of EGL-1 in exopher production and neuronal health in Caenorhabditis elegans. |
| Journal | bioRxiv |
| Abstract |
While traditionally studied for their pro-apoptotic functions, recent research suggests BH3-only proteins also have non-apoptotic roles. Here, we find that EGL-1, the BH3-only protein in Caenorhabditis elegans, promotes the cell-autonomous production of exophers in adult neurons. Exophers are large, micron-scale vesicles that are ejected from the cell and contain cellular components such as mitochondria. EGL-1 facilitates exopher production potentially through regulation of mitochondrial dynamics. Moreover, an endogenous, low level of EGL-1 expression appears to benefit dendritic health. Our findings provide insights into the mechanistic role of BH3-only protein in mitochondrial dynamics, downstream exopher production, and ultimately neuronal health. |
| Published | 2024-4-24 |
| DOI | 10.1101/2024.04.19.590348 |
| PII | 2024.04.19.590348 |
| PMID | 38712027 |
| PMC | PMC11071422 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1108 tm1133 |