論文 - 詳細
| RRC ID | 83975 |
|---|---|
| 著者 | Wu Z, Cardona EA, Pierce JT. |
| タイトル | Non-apoptotic role of EGL-1 in exopher production and neuronal health in Caenorhabditis elegans. |
| ジャーナル | bioRxiv |
| Abstract |
While traditionally studied for their pro-apoptotic functions, recent research suggests BH3-only proteins also have non-apoptotic roles. Here, we find that EGL-1, the BH3-only protein in Caenorhabditis elegans, promotes the cell-autonomous production of exophers in adult neurons. Exophers are large, micron-scale vesicles that are ejected from the cell and contain cellular components such as mitochondria. EGL-1 facilitates exopher production potentially through regulation of mitochondrial dynamics. Moreover, an endogenous, low level of EGL-1 expression appears to benefit dendritic health. Our findings provide insights into the mechanistic role of BH3-only protein in mitochondrial dynamics, downstream exopher production, and ultimately neuronal health. |
| 公開日 | 2024-4-24 |
| DOI | 10.1101/2024.04.19.590348 |
| PII | 2024.04.19.590348 |
| PMID | 38712027 |
| PMC | PMC11071422 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1108 tm1133 |