論文 - 詳細
| RRC ID | 84002 |
|---|---|
| 著者 | Charmpilas N, Sotiriou A, Axarlis K, Tavernarakis N, Hoppe T. |
| タイトル | Reproductive regulation of the mitochondrial stress response in Caenorhabditis elegans. |
| ジャーナル | Cell Rep |
| Abstract |
Proteome integrity is fundamental for cellular and organismal homeostasis. The mitochondrial unfolded protein response (UPRmt), a key component of the proteostasis network, is activated in a non-cell-autonomous manner in response to mitochondrial stress in distal tissues. However, the importance of inter-tissue communication for UPRmt inducibility under physiological conditions remains elusive. Here, we show that an intact germline is essential for robust UPRmt induction in the Caenorhabditis elegans somatic tissues. A series of nematode mutants with germline defects are unable to respond to genetic or chemical UPRmt inducers. Our genetic analysis suggests that reproductive signals, rather than germline stem cells, are responsible for somatic UPRmt induction. Consistent with this observation, we show that UPRmt is sexually dimorphic, as male nematodes are inherently unresponsive to mitochondrial stress. Our findings highlight a paradigm of germline-somatic communication and suggest that reproductive cessation is a primary cause of age-related UPRmt decline. |
| 巻・号 | 43(6) |
| ページ | 114336 |
| 公開日 | 2024-6-25 |
| DOI | 10.1016/j.celrep.2024.114336 |
| PII | S2211-1247(24)00664-8 |
| PMID | 38852157 |
| MeSH | Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Female Germ Cells* / metabolism Male Mitochondria* / metabolism Reproduction* Stress, Physiological Unfolded Protein Response* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm5919 tm4525 tm5519 |