論文 - 詳細
| RRC ID | 84004 |
|---|---|
| 著者 | Peysson A, Zariohi N, Gendrel M, Chambert-Loir A, Frébault N, Cheynet E, Andrini O, Boulin T. |
| タイトル | Wnt-Ror-Dvl signalling and the dystrophin complex organize planar-polarized membrane compartments in C. elegans muscles. |
| ジャーナル | Nat Commun |
| Abstract |
Cell polarity mechanisms allow the formation of specialized membrane domains with unique protein compositions, signalling properties, and functional characteristics. By analyzing the localization of potassium channels and proteins belonging to the dystrophin-associated protein complex, we reveal the existence of distinct planar-polarized membrane compartments at the surface of C. elegans muscle cells. We find that muscle polarity is controlled by a non-canonical Wnt signalling cascade involving the ligand EGL-20/Wnt, the receptor CAM-1/Ror, and the intracellular effector DSH-1/Dishevelled. Interestingly, classical planar cell polarity proteins are not required for this process. Using time-resolved protein degradation, we demonstrate that -while it is essentially in place by the end of embryogenesis- muscle polarity is a dynamic state, requiring continued presence of DSH-1 throughout post-embryonic life. Our results reveal the unsuspected complexity of the C. elegans muscle membrane and establish a genetically tractable model system to study cellular polarity and membrane compartmentalization in vivo. |
| 巻・号 | 15(1) |
| ページ | 4935 |
| 公開日 | 2024-6-10 |
| DOI | 10.1038/s41467-024-49154-8 |
| PII | 10.1038/s41467-024-49154-8 |
| PMID | 38858388 |
| PMC | PMC11164867 |
| MeSH | Animals Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Cell Membrane / metabolism Cell Polarity* Dishevelled Proteins / genetics Dishevelled Proteins / metabolism Dystrophin* / genetics Dystrophin* / metabolism Dystrophin-Associated Protein Complex / genetics Dystrophin-Associated Protein Complex / metabolism Muscles* / metabolism Receptor Tyrosine Kinase-like Orphan Receptors / genetics Receptor Tyrosine Kinase-like Orphan Receptors / metabolism Signal Transduction Wnt Proteins / metabolism Wnt Signaling Pathway* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1232 tm306 |