論文 - 詳細
| RRC ID | 84028 |
|---|---|
| 著者 | Horikawa M, Fukuyama M, Antebi A, Mizunuma M. |
| タイトル | Regulatory mechanism of cold-inducible diapause in Caenorhabditis elegans. |
| ジャーナル | Nat Commun |
| Abstract |
Temperature is a critical environmental cue that controls the development and lifespan of many animal species; however, mechanisms underlying low-temperature adaptation are poorly understood. Here, we describe cold-inducible diapause (CID), another type of diapause induced by low temperatures in Caenorhabditis elegans. A premature stop codon in heat shock factor 1 (hsf-1) triggers entry into CID at 9 °C, whereas wild-type animals enter CID at 4 °C. Furthermore, both wild-type and hsf-1(sy441) mutant animals undergoing CID can survive for weeks, and resume growth at 20 °C. Using epistasis analysis, we demonstrate that neural signalling pathways, namely tyraminergic and neuromedin U signalling, regulate entry into CID of the hsf-1 mutant. Overexpression of anti-ageing genes, such as hsf-1, XBP1/xbp-1, FOXO/daf-16, Nrf2/skn-1, and TFEB/hlh-30, also inhibits CID entry of the hsf-1 mutant. Based on these findings, we hypothesise that regulators of the hsf-1 mutant CID may impact longevity, and successfully isolate 16 long-lived mutants among 49 non-CID mutants via genetic screening. Furthermore, we demonstrate that the nonsense mutation of MED23/sur-2 prevents CID entry of the hsf-1(sy441) mutant and extends lifespan. Thus, CID is a powerful model to investigate neural networks involving cold acclimation and to explore new ageing mechanisms. |
| 巻・号 | 15(1) |
| ページ | 5793 |
| 公開日 | 2024-7-10 |
| DOI | 10.1038/s41467-024-50111-8 |
| PII | 10.1038/s41467-024-50111-8 |
| PMID | 38987256 |
| PMC | PMC11237089 |
| MeSH | Animals Basic Helix-Loop-Helix Transcription Factors Caenorhabditis elegans* / genetics Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Carrier Proteins Codon, Nonsense / genetics Cold Temperature* DNA-Binding Proteins* / genetics DNA-Binding Proteins* / metabolism Diapause* / genetics Diapause* / physiology Forkhead Transcription Factors / genetics Forkhead Transcription Factors / metabolism Longevity* / genetics Mutation Neuropeptides / genetics Neuropeptides / metabolism Signal Transduction Transcription Factors* / genetics Transcription Factors* / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3410 tm515 tm1978 tm2318 tm3262 |