論文 - 詳細
| RRC ID | 84059 |
|---|---|
| 著者 | Kohlbrenner T, Berger S, Laranjeira AC, Aegerter-Wilmsen T, Comi LF, deMello A, Hajnal A. |
| タイトル | Actomyosin-mediated apical constriction promotes physiological germ cell death in C. elegans. |
| ジャーナル | PLoS Biol |
| Abstract |
Germ cell apoptosis in Caenorhabditis elegans hermaphrodites is a physiological process eliminating around 60% of all cells in meiotic prophase to maintain tissue homeostasis. In contrast to programmed cell death in the C. elegans soma, the selection of germ cells undergoing apoptosis is stochastic. By live-tracking individual germ cells at the pachytene stage, we found that germ cells smaller than their neighbors are selectively eliminated through apoptosis before differentiating into oocytes. Thus, cell size is a strong predictor of physiological germ cell death. The RAS/MAPK and ECT/RHO/ROCK pathways together regulate germ cell size by controlling actomyosin constriction at the apical rachis bridges, which are cellular openings connecting the syncytial germ cells to a shared cytoplasmic core. Enhancing apical constriction reduces germ cell size and increases the rate of cell death while inhibiting the actomyosin network in the germ cells prevents their death. We propose that actomyosin contractility at the rachis bridges of the syncytial germ cells amplifies intrinsic disparities in cell size. Through this mechanism, the animals can adjust the balance between physiological germ cell death and oocyte differentiation. |
| 巻・号 | 22(8) |
| ページ | e3002775 |
| 公開日 | 2024-8-1 |
| DOI | 10.1371/journal.pbio.3002775 |
| PII | PBIOLOGY-D-23-02213 |
| PMID | 39178318 |
| PMC | PMC11376560 |
| MeSH | Actomyosin* / metabolism Animals Apoptosis* Caenorhabditis elegans* / metabolism Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Cell Differentiation Cell Size Germ Cells* / metabolism Oocytes / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1458 |