Reference - Detail
| RRC ID | 84062 |
|---|---|
| Author | Eroglu M, Zocher T, McAuley J, Webster R, Xiao MZX, Yu B, Mok C, Derry WB. |
| Title | Noncanonical inheritance of phenotypic information by protein amyloids. |
| Journal | Nat Cell Biol |
| Abstract |
All known heritable phenotypic information in animals is transmitted by direct inheritance of nucleic acids, their covalent modifications or histone modifications that modulate expression of associated genomic regions. Nonetheless, numerous familial traits and disorders cannot be attributed to known heritable molecular factors. Here we identify amyloid-like protein structures that are stably inherited in wild-type animals and influence traits. Their perturbation by genetic, environmental or pharmacological treatments leads to developmental phenotypes that can be epigenetically passed onto progeny. Injection of amyloids isolated from different phenotypic backgrounds into naive animals recapitulates the associated phenotype in offspring. Genetic and proteomic analyses reveal that the 26S proteasome and its conserved regulators maintain heritable amyloids across generations, which enables proper germ cell sex differentiation. We propose that inheritance of a proteinaceous epigenetic memory coordinates developmental timing and patterning with the environment to confer adaptive fitness. |
| Volume | 26(10) |
| Pages | 1712-1724 |
| Published | 2024-10-1 |
| DOI | 10.1038/s41556-024-01494-9 |
| PII | 10.1038/s41556-024-01494-9 |
| PMID | 39223373 |
| MeSH | Amyloid* / metabolism Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Epigenesis, Genetic* Female Germ Cells / drug effects Germ Cells / metabolism Inheritance Patterns / genetics Male Phenotype* Proteasome Endopeptidase Complex / genetics Proteasome Endopeptidase Complex / metabolism Proteomics / methods Sex Differentiation / genetics |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 786 |
| Altmetric score changes over past 6months | 9.5 |
| Resource | |
| C.elegans | tm872 |