| RRC ID |
84090
|
| Author |
Zhou L, Jiang L, Li L, Ma C, Xia P, Ding W, Liu Y.
|
| Title |
A germline-to-soma signal triggers an age-related decline of mitochondrial stress response.
|
| Journal |
Nat Commun
|
| Abstract |
The abilities of an organism to cope with extrinsic stresses and activate cellular stress responses decline during aging. The signals that modulate stress responses in aged animals remain to be elucidated. Here, we discover that feeding Caenorhabditis elegans (C. elegans) embryo lysates to adult worms enabled the animals to activate the mitochondrial unfolded protein response (UPRmt) upon mitochondrial perturbations. This discovery led to subsequent investigations that unveil a hedgehog-like signal that is transmitted from the germline to the soma in adults to inhibit UPRmt in somatic tissues. Additionally, we find that the levels of germline-expressed piRNAs in adult animals markedly decreased. This reduction in piRNA levels coincides with the production and secretion of a hedgehog-like signal and suppression of the UPRmt in somatic cells. Building upon existing research, our study further elucidates the intricate mechanisms of germline-to-soma signaling and its role in modulating the trade-offs between reproduction and somatic maintenance within the context of organismal aging.
|
| Volume |
15(1)
|
| Pages |
8723
|
| Published |
2024-10-8
|
| DOI |
10.1038/s41467-024-53064-0
|
| PII |
10.1038/s41467-024-53064-0
|
| PMID |
39379393
|
| PMC |
PMC11461804
|
| MeSH |
Aging* / genetics
Aging* / physiology
Animals
Caenorhabditis elegans* / genetics
Caenorhabditis elegans* / metabolism
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Germ Cells* / metabolism
Hedgehog Proteins / genetics
Hedgehog Proteins / metabolism
Mitochondria* / metabolism
RNA, Small Interfering* / genetics
RNA, Small Interfering* / metabolism
Signal Transduction*
Stress, Physiological
Unfolded Protein Response*
|
| Resource |
| C.elegans |
tm1200
tm4525
tm8237 |
