| RRC ID |
84102
|
| Author |
Sheng Y, Abreu A, Markovich Z, Ebea P, Davis L, Park E, Sheng P, Xie M, Han SM, Xiao R.
|
| Title |
A mitochondrial unfolded protein response-independent role of DVE-1 in longevity regulation.
|
| Journal |
Cell Rep
|
| Abstract |
The special AT-rich sequence-binding (SATB) protein DVE-1 is widely recognized for its pivotal involvement in orchestrating the retrograde mitochondrial unfolded protein response (mitoUPR) in C. elegans. In our study of downstream factors contributing to lifespan extension in sensory ciliary mutants, we find that DVE-1 is crucial for this longevity effect independent of its canonical mitoUPR function. Additionally, DVE-1 also influences lifespan under conditions of dietary restriction and germline loss, again distinct from its role in mitoUPR. Mechanistically, while mitochondrial stress typically prompts nuclear accumulation of DVE-1 to initiate the transcriptional mitoUPR program, these long-lived mutants reduce DVE-1 nuclear accumulation, likely by enhancing its cytosolic translocation. This observation suggests a cytosolic role for DVE-1 in lifespan extension. Overall, our study implies that, in contrast to the more narrowly defined role of the mitoUPR-related transcription factor ATFS-1, DVE-1 may possess broader functions than previously recognized in modulating longevity and defending against stress.
|
| Volume |
43(11)
|
| Pages |
114889
|
| Published |
2024-11-26
|
| DOI |
10.1016/j.celrep.2024.114889
|
| PII |
S2211-1247(24)01240-3
|
| PMID |
39423131
|
| PMC |
PMC11648574
|
| MeSH |
Animals
Caenorhabditis elegans* / metabolism
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Longevity* / physiology
Mitochondria* / metabolism
Mutation / genetics
Transcription Factors / metabolism
Unfolded Protein Response*
|
| Resource |
| C.elegans |
tm4803
tm7599
tm324 |
