論文 - 詳細
| RRC ID | 84121 |
|---|---|
| 著者 | Heestand B, McCarthy B, Simon M, Lister-Shimauchi EH, Frenk S, Ahmed S. |
| タイトル | Piwi mutant germ cells transmit a form of heritable stress that promotes longevity. |
| ジャーナル | Aging Cell |
| Abstract |
The C. elegans Argonaute protein PRG-1/Piwi and associated piRNAs protect metazoan genomes by silencing transposons and other types of foreign DNA. As prg-1 mutants are propagated, their fertility deteriorates prior to the onset of a reproductive arrest phenotype that resembles a starvation-induced stress response. We found that late-generation prg-1 mutants with substantially reduced fertility were long-lived, whereas early- or mid-generation prg-1 mutants had normal lifespans. Loss of the stress response transcription factor DAF-16 caused mid- or late-generation prg-1 mutants to live very short lives, whereas overexpression of DAF-16 enabled both mid- and late-generation prg-1 mutants to live long. Cytoplasmic P-bodies that respond to stress increased in long-lived late-generation prg-1 mutants and were transmitted to F1 but not F2 cross-progeny. Moreover, moderate levels of heritable stress shorten late-generation prg-1 mutant longevity when DAF-16 or P bodies are deficient. Together, these results suggest that the longevity of late-generation prg-1 mutants is a hormetic stress response. However, dauer larvae that occur in response to stress were not observed in late-generation prg-1 mutants. Small germ cell nucleoli that depended on germline DAF-16 were present in late-generation prg-1 mutants but were not necessary for their longevity. We propose that prg-1 mutant germ cells transmit a form of heritable stress, high levels of which promote longevity and strongly reduce fertility. The heritable stress transmitted by prg-1/Piwi mutant germ cells may be generally relevant to epigenetic inheritance of longevity. |
| 巻・号 | 24(1) |
| ページ | e14350 |
| 公開日 | 2025-1-1 |
| DOI | 10.1111/acel.14350 |
| PMID | 39520150 |
| PMC | PMC11709112 |
| MeSH | Animals Argonaute Proteins* / genetics Argonaute Proteins* / metabolism Caenorhabditis elegans* / genetics Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Fertility / genetics Forkhead Transcription Factors / genetics Forkhead Transcription Factors / metabolism Germ Cells* / metabolism Longevity* / genetics Mutation Stress, Physiological* / genetics Transcription Factors / genetics Transcription Factors / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm872 |