論文 - 詳細
| RRC ID | 84125 |
|---|---|
| 著者 | Molina-García L, Colinas-Fischer S, Benavides-Laconcha S, Lin L, Clark E, Treloar NJ, García-Minaur-Ortíz B, Butts M, Barnes CP, Barrios A. |
| タイトル | Conflict during learning reconfigures the neural representation of positive valence and approach behavior. |
| ジャーナル | Curr Biol |
| Abstract |
Punishing and rewarding experiences can change the valence of sensory stimuli and guide animal behavior in opposite directions, resulting in avoidance or approach. Often, however, a stimulus is encountered with both positive and negative experiences. How is such conflicting information represented in the brain and resolved into a behavioral decision? We address this question by dissecting a circuit for sexual conditioning in C. elegans. In this learning paradigm, an odor is conditioned with both a punishment (starvation) and a reward (mates), resulting in odor approach. We find that negative and positive experiences are both encoded by the neuropeptide pigment dispersing factor 1 (PDF-1) being released from, and acting on, different neurons. Each experience creates a distinct memory in the circuit for odor processing. This results in the sensorimotor representation of the odor being different in naive and sexually conditioned animals, despite both displaying approach. Our results reveal that the positive valence of a stimulus is not represented in the activity of any single neuron class but flexibly represented within the circuit according to the experiences and predictions associated with the stimulus. |
| 巻・号 | 34(23) |
| ページ | 5470-5483.e7 |
| 公開日 | 2024-12-2 |
| DOI | 10.1016/j.cub.2024.10.024 |
| PII | S0960-9822(24)01378-2 |
| PMID | 39547234 |
| MeSH | Animals Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Conflict, Psychological Learning / physiology Neurons / physiology Neuropeptides / metabolism Odorants Punishment Reward Sexual Behavior, Animal / physiology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 27 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4393 tm1996 tm4457 |