Reference - Detail
| RRC ID | 84138 |
|---|---|
| Author | Liu Y, Li Q, Tian G, Zhou X, Chen P, Chen B, Shan Z, Qi B. |
| Title | Neuronal PRDX-2-Mediated ROS Signaling Regulates Food Digestion via peripheral UPRmt Activation. |
| Journal | Nat Commun |
| Abstract |
All organisms depend on food digestion for survival, yet the brain-gut signaling mechanisms that regulate this process are not fully understood. Here, using an established C. elegans digestion model, we uncover a pathway in which neuronal ROS (free radicals) signal the intestine to suppress digestion. Genetic screening reveals that reducing genes responsible for maintaining ROS balance increases free radicals and decreases digestion. PRDX-2 knockout in olfactory neurons (AWC) elevates ROS and reduces digestive capacity, mediated by the neuropeptide NLP-1 and activation of the mitochondrial unfolded protein response (UPRmt) in the intestine. Additionally, over-expressing nlp-1 or ablating AWC neurons both trigger UPRmt and inhibit digestion. These findings reveal a brain-gut connection in which neuronal PRDX-2-mediated ROS signaling modulates food digestion, highlighting a critical role of free radicals in shutting down digestion to alleviate stress and reduce food consumption. |
| Volume | 15(1) |
| Pages | 10582 |
| Published | 2024-12-4 |
| DOI | 10.1038/s41467-024-55013-3 |
| PII | 10.1038/s41467-024-55013-3 |
| PMID | 39632952 |
| PMC | PMC11618335 |
| MeSH | Animals Animals, Genetically Modified Brain-Gut Axis* / physiology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Digestion* / physiology Gene Knockout Techniques Intestines / metabolism Mitochondria / metabolism Neuropeptides / metabolism Olfactory Receptor Neurons* / metabolism Peroxiredoxins* / genetics Peroxiredoxins* / metabolism Reactive Oxygen Species* / metabolism Signal Transduction / physiology Unfolded Protein Response / genetics |
| Altmetric score |
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| The most frequently cited source | Bluesky |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm760 tm4525 |