論文 - 詳細
| RRC ID | 84138 |
|---|---|
| 著者 | Liu Y, Li Q, Tian G, Zhou X, Chen P, Chen B, Shan Z, Qi B. |
| タイトル | Neuronal PRDX-2-Mediated ROS Signaling Regulates Food Digestion via peripheral UPRmt Activation. |
| ジャーナル | Nat Commun |
| Abstract |
All organisms depend on food digestion for survival, yet the brain-gut signaling mechanisms that regulate this process are not fully understood. Here, using an established C. elegans digestion model, we uncover a pathway in which neuronal ROS (free radicals) signal the intestine to suppress digestion. Genetic screening reveals that reducing genes responsible for maintaining ROS balance increases free radicals and decreases digestion. PRDX-2 knockout in olfactory neurons (AWC) elevates ROS and reduces digestive capacity, mediated by the neuropeptide NLP-1 and activation of the mitochondrial unfolded protein response (UPRmt) in the intestine. Additionally, over-expressing nlp-1 or ablating AWC neurons both trigger UPRmt and inhibit digestion. These findings reveal a brain-gut connection in which neuronal PRDX-2-mediated ROS signaling modulates food digestion, highlighting a critical role of free radicals in shutting down digestion to alleviate stress and reduce food consumption. |
| 巻・号 | 15(1) |
| ページ | 10582 |
| 公開日 | 2024-12-4 |
| DOI | 10.1038/s41467-024-55013-3 |
| PII | 10.1038/s41467-024-55013-3 |
| PMID | 39632952 |
| PMC | PMC11618335 |
| MeSH | Animals Animals, Genetically Modified Brain-Gut Axis* / physiology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Digestion* / physiology Gene Knockout Techniques Intestines / metabolism Mitochondria / metabolism Neuropeptides / metabolism Olfactory Receptor Neurons* / metabolism Peroxiredoxins* / genetics Peroxiredoxins* / metabolism Reactive Oxygen Species* / metabolism Signal Transduction / physiology Unfolded Protein Response / genetics |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm760 tm4525 |