論文 - 詳細
| RRC ID | 84147 |
|---|---|
| 著者 | Pender CL, Dishart JG, Gildea HK, Nauta KM, Page EM, Siddiqi TF, Cheung SS, Joe L, Burton NO, Dillin A. |
| タイトル | Perception of a pathogenic signature initiates intergenerational protection. |
| ジャーナル | Cell |
| Abstract |
Transmission of immune responses from one generation to the next represents a powerful adaptive mechanism to protect an organism's descendants. Parental infection by the natural C. elegans pathogen Pseudomonas vranovensis induces a protective response in progeny, but the bacterial cues and intergenerational signal driving this response were previously unknown. Here, we find that animals activate a protective stress response program upon exposure to P. vranovensis-derived cyanide and that a metabolic byproduct of cyanide detoxification, β-cyanoalanine, acts as an intergenerational signal to protect progeny from infection. Remarkably, this mechanism does not require direct parental infection; rather, exposure to pathogen-derived volatiles is sufficient to enhance the survival of the next generation, indicating that parental surveillance of environmental cues can activate a protective intergenerational response. Therefore, the mere perception of a pathogen-derived toxin, in this case cyanide, can protect an animal's progeny from future pathogenic challenges. |
| 巻・号 | 188(3) |
| ページ | 594-605.e10 |
| 公開日 | 2025-2-6 |
| DOI | 10.1016/j.cell.2024.11.026 |
| PII | S0092-8674(24)01342-4 |
| PMID | 39721586 |
| MeSH | Alanine / analogs & derivatives Alanine / metabolism Animals Caenorhabditis elegans* / immunology Caenorhabditis elegans* / microbiology Cyanides / metabolism Nitriles / metabolism Pseudomonas* / metabolism Pseudomonas* / pathogenicity Pseudomonas Infections / immunology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2182 |