論文 - 詳細
| RRC ID | 84200 |
|---|---|
| 著者 | Xue W, Chen Y, Lei Z, Wang Y, Liu J, Wen X, Xu F, Chen P, Wu Z, Jin YN, Yu YV. |
| タイトル | Calcium levels in ASER neurons determine behavioral valence by engaging distinct neuronal circuits in C. elegans. |
| ジャーナル | Nat Commun |
| Abstract |
The valence of stimuli is shaped by various factors, including environmental cues, internal states, genetic variability, and past experience. However, the mechanisms behind this flexibility remain elusive. In the nematode C. elegans, we found that ethanol, an olfactory stimulus, can elicit opposite chemotaxis responses - attraction vs. aversion - depending on NaCl concentration, demonstrating the role of environmental factors in altering valence. Remarkably, a single chemosensory neuron, ASER, orchestrate this bidirectional ethanol chemotaxis by integrating information from both stimuli - ethanol and NaCl - into its neuronal activity dynamics. Specifically, different calcium dynamics in the ASER neuron differentially activate the signaling molecule CMK-1, thereby engaging different downstream interneurons and leading to opposite chemotaxis directions. Consistently, optogenetic manipulations of the ASER neuron reverse the chemotaxis directions, by altering its calcium dynamics. Our findings reveal a mechanism by which a single neuron integrates multisensory inputs to determine context-dependent behavioral valence, contributing to our current understanding of valence encoding. |
| 巻・号 | 16(1) |
| ページ | 1814 |
| 公開日 | 2025-2-20 |
| DOI | 10.1038/s41467-025-57051-x |
| PII | 10.1038/s41467-025-57051-x |
| PMID | 39979341 |
| PMC | PMC11842750 |
| MeSH | Animals Animals, Genetically Modified Behavior, Animal / physiology Caenorhabditis elegans* / metabolism Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Calcium* / metabolism Chemotaxis / drug effects Chemotaxis / physiology Ethanol / pharmacology Interneurons / metabolism Interneurons / physiology Neurons* / metabolism Neurons* / physiology Optogenetics Sodium Chloride / pharmacology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm2569 tm2990 tm1782 tm1875 tm1811 |