| RRC ID |
84221
|
| Author |
Li Y, Wang C, Fu X, Wu D, He C, Dai W, Yue X, Luo Z, Yang J, Wan QL.
|
| Title |
Transgenerational inheritance of mitochondrial hormetic oxidative stress mediated by histone H3K4me3 and H3K27me3 modifications.
|
| Journal |
Redox Biol
|
| Abstract |
Mitochondrial hormetic oxidative stress (mtHOS) is crucial in physiology and disease; however, its effects on epigenetic inheritance and organism fitness across generations remains elusive. Utilizing the C. elegans as a model, we elucidate that parental exposure to mtHOS not only elicits a lifespan extension in the exposed individuals but also confers this longevity advantage to the progeny through the transgenerational epigenetic inheritance (TEI) mechanism. This transgenerational transmission of lifespan prolongation depends on the activation of the UPRmt and the synergistic action of the transcription factors DAF-16/FOXO and SKN-1/Nrf2. Additionally, the H3K4me3 and H3K27me3 serve as epigenetic mediators, selectively marking and regulating the expression of genes associated with oxidative stress response and longevity determination. Our findings illuminate the mechanisms underlying the implementation and transmission of mtHOS, revealing a sophisticated interplay among oxidative stress response genes and chromatin remodeling that collectively enhances the progeny's adaptive resilience to future challenges.
|
| Volume |
82
|
| Pages |
103598
|
| Published |
2025-5-1
|
| DOI |
10.1016/j.redox.2025.103598
|
| PII |
S2213-2317(25)00111-9
|
| PMID |
40112613
|
| PMC |
PMC11979432
|
| MeSH |
Animals
Caenorhabditis elegans* / genetics
Caenorhabditis elegans* / metabolism
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism
DNA-Binding Proteins
Epigenesis, Genetic
Forkhead Transcription Factors / genetics
Forkhead Transcription Factors / metabolism
Histones* / genetics
Histones* / metabolism
Hormesis*
Longevity / genetics
Mitochondria* / genetics
Mitochondria* / metabolism
Oxidative Stress* / genetics
Transcription Factors / genetics
Transcription Factors / metabolism
|
| Resource |
| C.elegans |
tm4803
tm4919 |
