論文 - 詳細
| RRC ID | 84255 |
|---|---|
| 著者 | Aoki K, Higuchi T, Akieda Y, Matsubara K, Ohkawa Y, Ishitani T. |
| タイトル | Mechano-gradients drive morphogen-noise correction to ensure robust patterning. |
| ジャーナル | Sci Adv |
| Abstract |
Morphogen gradients instruct cells to pattern tissues. Although the mechanisms by which morphogens transduce chemical signals have been extensively studied, the roles and regulation of the physical communication between morphogen-receiver cells remain unclear. Here, we show that the Wnt/β-catenin-morphogen gradient, which patterns the embryonic anterior-posterior (AP) axis, generates intercellular tension gradients along the AP axis by controlling membrane cadherin levels in zebrafish embryos. This "mechano-gradient" is used for the cell competition-driven correction of noisy morphogen gradients. Naturally and artificially generated unfit cells, producing noisy Wnt/β-catenin gradients, induce local deformation of the mechano-gradients that activate mechanosensitive calcium channels in the neighboring fit cells, which then secrete annexin A1a to kill unfit cells. Thus, chemo-mechanical interconversion-mediated competitive communication between the morphogen-receiver cells ensures precise tissue patterning. |
| 巻・号 | 10(46) |
| ページ | eadp2357 |
| 公開日 | 2024-11-15 |
| DOI | 10.1126/sciadv.adp2357 |
| PMID | 39546611 |
| PMC | PMC11567007 |
| MeSH | Animals Body Patterning* Cadherins* / genetics Cadherins* / metabolism Embryo, Nonmammalian / metabolism Mechanotransduction, Cellular Morphogenesis Wnt Signaling Pathway Zebrafish* / embryology Zebrafish Proteins / genetics Zebrafish Proteins / metabolism beta Catenin / genetics beta Catenin / metabolism |
| IF | 13.117 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 28 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(6xTcf/LefBS-miniP:d2EGFP)isi04 |