| RRC ID |
84255
|
| 著者 |
Aoki K, Higuchi T, Akieda Y, Matsubara K, Ohkawa Y, Ishitani T.
|
| タイトル |
Mechano-gradients drive morphogen-noise correction to ensure robust patterning.
|
| ジャーナル |
Sci Adv
|
| Abstract |
Morphogen gradients instruct cells to pattern tissues. Although the mechanisms by which morphogens transduce chemical signals have been extensively studied, the roles and regulation of the physical communication between morphogen-receiver cells remain unclear. Here, we show that the Wnt/β-catenin-morphogen gradient, which patterns the embryonic anterior-posterior (AP) axis, generates intercellular tension gradients along the AP axis by controlling membrane cadherin levels in zebrafish embryos. This "mechano-gradient" is used for the cell competition-driven correction of noisy morphogen gradients. Naturally and artificially generated unfit cells, producing noisy Wnt/β-catenin gradients, induce local deformation of the mechano-gradients that activate mechanosensitive calcium channels in the neighboring fit cells, which then secrete annexin A1a to kill unfit cells. Thus, chemo-mechanical interconversion-mediated competitive communication between the morphogen-receiver cells ensures precise tissue patterning.
|
| 巻・号 |
10(46)
|
| ページ |
eadp2357
|
| 公開日 |
2024-11-15
|
| DOI |
10.1126/sciadv.adp2357
|
| PMID |
39546611
|
| PMC |
PMC11567007
|
| MeSH |
Animals
Body Patterning*
Cadherins* / genetics
Cadherins* / metabolism
Embryo, Nonmammalian / metabolism
Mechanotransduction, Cellular
Morphogenesis
Wnt Signaling Pathway
Zebrafish* / embryology
Zebrafish Proteins / genetics
Zebrafish Proteins / metabolism
beta Catenin / genetics
beta Catenin / metabolism
|
| IF |
13.117
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(6xTcf/LefBS-miniP:d2EGFP)isi04 |
