| RRC ID |
84370
|
| Author |
Sakai A, Yamada T, Maruyama M, Ueda K, Miyasaka T, Yoshida H, Suzuki H.
|
| Title |
Exploration for Blood Biomarkers of Human Long Non-coding RNAs Predicting Oxaliplatin-Induced Chronic Neuropathy Through iPS Cell-Derived Sensory Neuron Analysis.
|
| Journal |
Mol Neurobiol
|
| Abstract |
Oxaliplatin, a platinum-based chemotherapeutic agent, frequently causes acute and chronic peripheral sensory neuropathy, for which no effective treatment has been established. In particular, chronic neuropathy can persist for years even after treatment completion, thus worsening patients' quality of life. To avoid the development of intractable adverse effects, a predictive biomarker early in treatment is awaited. In this study, we explored extracellular long non-coding RNAs (lncRNAs) released from primary sensory neurons as biomarker candidates for oxaliplatin-induced peripheral neuropathy. Because many human-specific lncRNA genes exist, we induced peripheral sensory neurons from human induced pluripotent stem cells. Oxaliplatin treatment changed the levels of many lncRNAs in extracellular vesicles (EVs) released from cultured primary sensory neurons. Among them, the levels of release of lncRNAs that were considered to be selectively expressed in dorsal root ganglia were correlated with those of lncRNAs in plasma EV obtained from healthy individuals. Several lncRNAs in plasma EVs early after the initiation of treatment showed greater changes in patients who did not develop chronic neuropathy that persisted for more than 1 year than in those who did. Therefore, these extracellular lncRNAs in plasma EVs may represent predictive biomarkers for the development of chronic peripheral neuropathy induced by oxaliplatin.
|
| Volume |
61(9)
|
| Pages |
7168-7180
|
| Published |
2024-9-1
|
| DOI |
10.1007/s12035-024-04017-7
|
| PII |
10.1007/s12035-024-04017-7
|
| PMID |
38374315
|
| MeSH |
Biomarkers* / blood
Biomarkers* / metabolism
Cells, Cultured
Chronic Disease
Extracellular Vesicles / drug effects
Extracellular Vesicles / metabolism
Female
Ganglia, Spinal / drug effects
Ganglia, Spinal / metabolism
Ganglia, Spinal / pathology
Humans
Induced Pluripotent Stem Cells* / metabolism
Male
Middle Aged
Oxaliplatin* / adverse effects
Peripheral Nervous System Diseases* / blood
Peripheral Nervous System Diseases* / chemically induced
Peripheral Nervous System Diseases* / pathology
RNA, Long Noncoding* / blood
RNA, Long Noncoding* / genetics
Sensory Receptor Cells* / drug effects
Sensory Receptor Cells* / metabolism
|
| Resource |
| Human and Animal Cells |
six human iPS cell lines established from distinct healthy |
