論文 - 詳細
| RRC ID | 84386 |
|---|---|
| 著者 | Sui L, Dahmann C. |
| タイトル | A cellular tilting mechanism important for dynamic tissue shape changes and cell differentiation in Drosophila. |
| ジャーナル | Dev Cell |
| Abstract |
Dynamic changes in three-dimensional cell shape are important for tissue form and function. In the developing Drosophila eye, photoreceptor differentiation requires the progression across the tissue of an epithelial fold known as the morphogenetic furrow. Morphogenetic furrow progression involves apical cell constriction and movement of apical cell edges. Here, we show that cells progressing through the morphogenetic furrow move their basal edges in opposite direction to their apical edges, resulting in a cellular tilting movement. We further demonstrate that cells generate, at their basal side, oriented, force-generating protrusions. Knockdown of the protein kinase Src42A or photoactivation of a dominant-negative form of the small GTPase Rac1 reduces protrusion formation. Impaired protrusion formation stalls basal cell movement and slows down morphogenetic furrow progression and photoreceptor differentiation. This work identifies a cellular tilting mechanism important for the generation of dynamic tissue shape changes and cell differentiation. |
| 巻・号 | 59(14) |
| ページ | 1794-1808.e5 |
| 公開日 | 2024-7-22 |
| DOI | 10.1016/j.devcel.2024.04.011 |
| PII | S1534-5807(24)00236-3 |
| PMID | 38692272 |
| MeSH | Animals Cell Differentiation* / physiology Cell Movement Cell Shape* Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* / cytology Drosophila melanogaster* / metabolism Morphogenesis* Photoreceptor Cells, Invertebrate* / cytology Photoreceptor Cells, Invertebrate* / metabolism Proto-Oncogene Proteins pp60(c-src) rac1 GTP-Binding Protein / genetics rac1 GTP-Binding Protein / metabolism |
| IF | 10.092 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 7873R-2 |