| RRC ID |
84407
|
| Author |
Shimizu S, Shin J, Ota T, Kondo H, Nakae S, Sudo K, Gaballah EM, Morita K, Osada Y.
|
| Title |
IL-10 is not required for the alleviation of collagen-induced arthritis by non-lethal malarial infection in mice.
|
| Journal |
Parasitol Int
|
| Abstract |
We previously reported that Plasmodium yoelii 17XNL (Py), a non-lethal rodent malarial parasite, could suppress collagen-induced arthritis (CIA) and increase the production of T cell-derived interleukin (IL)-10. However, it remained unclear whether IL-10 is essential for the Py-induced suppression of CIA. Male IL-10 knockout (KO) DBA/1 J mice were immunized with bovine type II collagen (CII) and subsequently infected with Py at one week post-immunization. The development of arthritis was evaluated by an arthritis score up to 6 weeks post-immunization. At 3 weeks post-immunization, cytokine production from splenocytes and serum anti-CII IgG/IgG1/IgG2a levels were compared between non-infected control mice and Py-infected mice. Py infection inhibited the development of CIA in IL-10KO mice until 4 weeks post-immunization, after which the arthritis score reached levels comparable with the control mice. Both pro-arthritic (IL-17 and TNF-α) and anti-arthritic (IFN-γ and IL-4) cytokines were down-regulated during the periods of parasitemia, while no significant differences were observed in levels of anti-CII IgG antibodies. Our findings indicate that Py alleviates CIA via IL-10-independent mechanisms.
|
| Volume |
104
|
| Pages |
102993
|
| Published |
2025-2-1
|
| DOI |
10.1016/j.parint.2024.102993
|
| PII |
S1383-5769(24)00144-2
|
| PMID |
39561958
|
| MeSH |
Animals
Arthritis, Experimental* / immunology
Cattle
Collagen Type II / immunology
Cytokines / metabolism
Immunoglobulin G / blood
Interleukin-10*
Malaria* / immunology
Malaria* / prevention & control
Male
Mice
Mice, Inbred DBA*
Mice, Knockout*
Plasmodium yoelii* / immunology
|
| IF |
1.866
|
| Resource |
| Pathogenic eukaryotic microorganisms |
Plasmodium yoelii 17XNL |
