論文 - 詳細
| RRC ID | 84799 |
|---|---|
| 著者 | Shigeno S, Kadowaki M, Nagai K, Hosoda K, Terahara T, Nishimura T, Hasegawa N, Tomoda H, Ohshiro T. |
| タイトル | New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
During our screening for anti-mycobacterial agents against Mycobacterium avium complex (MAC), two new polycyclic tetramate macrolactams (PTMs), named hydroxycapsimycin (1) and brokamycin (2), were isolated along with the known PTM, ikarugamycin (3), from the culture broth of marine-derived Streptomyces sp. KKMA-0239. The relative structures of 1 and 2 were elucidated by spectroscopic data analyses, including 1D and 2D NMR. Furthermore, the absolute configuration of 1 was confirmed by a single-crystal X-ray diffraction analysis. Compounds 2 and 3 exhibited moderate antimycobacterial activities against MAC, including clinically isolated drug-resistant M. avium. |
| 巻・号 | 77(5) |
| ページ | 265-271 |
| 公開日 | 2024-5-1 |
| DOI | 10.1038/s41429-024-00710-w |
| PII | 10.1038/s41429-024-00710-w |
| PMID | 38531967 |
| MeSH | Anti-Bacterial Agents* / chemistry Anti-Bacterial Agents* / isolation & purification Anti-Bacterial Agents* / pharmacology Antitubercular Agents / chemistry Antitubercular Agents / isolation & purification Antitubercular Agents / pharmacology Crystallography, X-Ray Lactams* Lactams, Macrocyclic / chemistry Lactams, Macrocyclic / isolation & purification Lactams, Macrocyclic / pharmacology Magnetic Resonance Spectroscopy Microbial Sensitivity Tests* Molecular Structure Mycobacterium avium Complex / drug effects Polycyclic Compounds / chemistry Polycyclic Compounds / isolation & purification Polycyclic Compounds / pharmacology Streptomyces* / chemistry Streptomyces* / metabolism |
| リソース情報 | |
| 一般微生物 | JCM15430 |