論文 - 詳細
| RRC ID | 84842 |
|---|---|
| 著者 | Kano R, Yamada T, Tamura T, Makimura K. |
| タイトル | Is milbemycin a game changer against antifungal drug-resistant mycoses? |
| ジャーナル | Med Mycol |
| Abstract |
Milbemycin oximes are macrocyclic lactones that have a broad spectrum of activity against nematode infection in animals. They are known to block drug efflux, which increases the susceptibility of fungi to azoles. We investigated the effects of milbemycin on the azole susceptibility of fungi (Aspergillus fumigatus, Candida albicans, C. auris, Cryptococcus neoformans, and Trichophyton rubrum). To screen for changes in azole susceptibility, fungal growth was tested on a culture medium containing 1 μg/ml milbemycin. The results showed that milbemycin increased the azole susceptibility of azole-resistant strains of C. albicans, C. auris, C. neoformans, and T. rubrum. Thus, milbemycin might be useful against antifungal drug-resistant strains. |
| 巻・号 | 62(2) |
| 公開日 | 2024-1-27 |
| DOI | 10.1093/mmy/myae003 |
| PII | 7591307 |
| PMID | 38285608 |
| MeSH | Animals Antifungal Agents / pharmacology Antifungal Agents / therapeutic use Azoles / pharmacology Cryptococcus neoformans* Drug Resistance, Fungal Macrolides* Microbial Sensitivity Tests / veterinary Mycoses* / veterinary |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM15448 |