Reference - Detail
| RRC ID | 84849 |
|---|---|
| Author | Nie Q, Luo X, Wang K, Ding Y, Jia S, Zhao Q, Li M, Zhang J, Zhuo Y, Lin J, Guo C, Zhang Z, Liu H, Zeng G, You J, Sun L, Lu H, Ma M, Jia Y, Zheng MH, Pang Y, Qiao J, Jiang C. |
| Title | Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway. |
| Journal | Cell |
| Abstract |
The gut microbiota has been found to play an important role in the progression of metabolic dysfunction-associated steatohepatitis (MASH), but the mechanisms have not been established. Here, by developing a click-chemistry-based enrichment strategy, we identified several microbial-derived bile acids, including the previously uncharacterized 3-succinylated cholic acid (3-sucCA), which is negatively correlated with liver damage in patients with liver-tissue-biopsy-proven metabolic dysfunction-associated fatty liver disease (MAFLD). By screening human bacterial isolates, we identified Bacteroides uniformis strains as effective producers of 3-sucCA both in vitro and in vivo. By activity-based protein purification and identification, we identified an enzyme annotated as β-lactamase in B. uniformis responsible for 3-sucCA biosynthesis. Furthermore, we found that 3-sucCA is a lumen-restricted metabolite and alleviates MASH by promoting the growth of Akkermansia muciniphila. Together, our data offer new insights into the gut microbiota-liver axis that may be leveraged to augment the management of MASH. |
| Volume | 187(11) |
| Pages | 2717-2734.e33 |
| Published | 2024-5-23 |
| DOI | 10.1016/j.cell.2024.03.034 |
| PII | S0092-8674(24)00350-7 |
| PMID | 38653239 |
| MeSH | Akkermansia* / metabolism Animals Bacteroides* / metabolism Bile Acids and Salts* / metabolism Biosynthetic Pathways / genetics Fatty Liver / metabolism Gastrointestinal Microbiome* Humans Liver / metabolism Male Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease* / metabolism Non-alcoholic Fatty Liver Disease* / microbiology Symbiosis* Verrucomicrobia / metabolism beta-Lactamases / metabolism |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 41 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM30893 |