論文 - 詳細
| RRC ID | 85078 |
|---|---|
| 著者 | Bogutz AB, Brind'Amour J, Kobayashi H, Jensen KN, Nakabayashi K, Imai H, Lorincz MC, Lefebvre L. |
| タイトル | Evolution of imprinting via lineage-specific insertion of retroviral promoters. |
| ジャーナル | Nat Commun |
| Abstract |
Imprinted genes are expressed from a single parental allele, with the other allele often silenced by DNA methylation (DNAme) established in the germline. While species-specific imprinted orthologues have been documented, the molecular mechanisms underlying the evolutionary switch from biallelic to imprinted expression are unknown. During mouse oogenesis, gametic differentially methylated regions (gDMRs) acquire DNAme in a transcription-guided manner. Here we show that oocyte transcription initiating in lineage-specific endogenous retroviruses (ERVs) is likely responsible for DNAme establishment at 4/6 mouse-specific and 17/110 human-specific imprinted gDMRs. The latter are divided into Catarrhini- or Hominoidea-specific gDMRs embedded within transcripts initiating in ERVs specific to these primate lineages. Strikingly, imprinting of the maternally methylated genes Impact and Slc38a4 was lost in the offspring of female mice harboring deletions of the relevant murine-specific ERVs upstream of these genes. Our work reveals an evolutionary mechanism whereby maternally silenced genes arise from biallelically expressed progenitors. |
| 巻・号 | 10(1) |
| ページ | 5674 |
| 公開日 | 2019-12-12 |
| DOI | 10.1038/s41467-019-13662-9 |
| PII | 10.1038/s41467-019-13662-9 |
| PMID | 31831741 |
| PMC | PMC6908575 |
| MeSH | Animals DNA Methylation* Epigenomics Evolution, Molecular* Female Genomic Imprinting* Germ Cells Haplorhini Humans Macaca Male Mice Oocytes / metabolism Pan troglodytes Primates Promoter Regions, Genetic / genetics* Retroviridae / genetics* Species Specificity Terminal Repeat Sequences |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 22 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| GAIN | chimpanzee rhesus macaque |