Reference - Detail
| RRC ID | 85211 |
|---|---|
| Author | Fukui H, Chow RW, Xie J, Foo YY, Yap CH, Minc N, Mochizuki N, Vermot J. |
| Title | Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces. |
| Journal | Science |
| Abstract |
Developing cardiovascular systems use mechanical forces to take shape, but how ubiquitous blood flow forces instruct local cardiac cell identity is still unclear. By manipulating mechanical forces in vivo, we show here that shear stress is necessary and sufficient to promote valvulogenesis. We found that valve formation is associated with the activation of an extracellular adenosine triphosphate (ATP)–dependent purinergic receptor pathway, specifically triggering calcium ion (Ca2+) pulses and nuclear factor of activated T cells 1 (Nfatc1) activation. Thus, mechanical forces are converted into discrete bioelectric signals by an ATP-Ca2+-Nfatc1–mechanosensitive pathway to generate positional information and control valve formation. |
| Volume | 374(6565) |
| Pages | 351-354 |
| Published | 2021-10-15 |
| DOI | 10.1126/science.abc6229 |
| PMID | 34648325 |
| MeSH | Adenosine Triphosphate / metabolism Animals Calcium / metabolism Calcium Signaling Electrophysiological Phenomena Endothelial Cells / physiology Heart Valves / cytology Heart Valves / growth & development* Heart Valves / metabolism NFATC Transcription Factors / metabolism Receptors, Purinergic P2 / metabolism Shear Strength* Stress, Mechanical* Zebrafish |
| IF | 41.846 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 172 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | UAS:RFP UAS:GCaMP7a |