論文 - 詳細
| RRC ID | 85383 |
|---|---|
| 著者 | Qin P, Wang Q, Wu Y, You Q, Li M, Guo Z. |
| タイトル | Age mosaic of gut epithelial cells prevents aging. |
| ジャーナル | Nat Commun |
| Abstract |
Improving gut health by altering the activity of intestinal stem cells is thought to have the potential to reverse aging. The aged Drosophila midgut undergoes hyperplasia and barrier dysfunction. However, it is still unclear how to limit hyperplasia to extend lifespan. Here, we show that early midgut injury prevents the abrupt onset of aging hyperplasia and extends lifespan in flies. Daily transcriptome profiling and lineage tracing analysis show that the abrupt onset of aging hyperplasia is due to the collective turnover of developmentally generated "old" enterocytes (ECs). Early injury introduces new ECs into the old EC population, forming the epithelial age mosaic. Age mosaic avoids collective EC turnover and facilitates septate junction formation, thereby improving the epithelial barrier and extending lifespan. Furthermore, we found that intermittent time-restricted feeding benefits health by creating an EC age mosaic. Our findings suggest that age mosaic may become a therapeutic approach to reverse aging. |
| 巻・号 | 16(1) |
| ページ | 6734 |
| 公開日 | 2025-7-22 |
| DOI | 10.1038/s41467-025-62043-y |
| PII | 10.1038/s41467-025-62043-y |
| PMID | 40695820 |
| PMC | PMC12284232 |
| MeSH | Aging* / genetics Aging* / physiology Animals Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster* / genetics Drosophila melanogaster* / physiology Enterocytes / cytology Enterocytes / metabolism Epithelial Cells* / cytology Epithelial Cells* / metabolism Gene Expression Profiling Hyperplasia Intestinal Mucosa* / cytology Intestinal Mucosa* / metabolism Intestines / cytology Longevity / physiology Stem Cells / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 12074R-1 11415R-2 |