論文 - 詳細
| RRC ID | 85880 |
|---|---|
| 著者 | Tatsumi Y, Masuda T, Watanabe T, Utomo RY, Zulfin UM, Meiyanto E, Ozaki T, Suenaga Y, Kamikubo Y. |
| タイトル | Antitumor effect of curcumin analog on osteosarcoma through the inhibition of p300‑mediated histone acetylation. |
| ジャーナル | Oncol Rep |
| Abstract |
Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. Histone acetyltransferases (HATs), such as p300, CBP and PCAF, modulate numerous biological processes, including cellular proliferation and oncogenesis, through histone acetylation. In the present study, it was investigated whether the curcumin analogs such as pentagamavunon‑1 (PGV‑1) and chemoprevention curcumin analog‑1.1 (CCA‑1.1) could target p300 and suppress OS. Computational analysis indicated that PGV‑1 and CCA‑1.1 bind to the HAT domain of p300. Accordingly, these analogs efficiently inhibited the HAT activity of p300 in vitro and promoted OS cell apoptosis, accompanied by downregulation of acetylated histone H3 at Lys‑27 and phosphorylated oncogenic STAT3 at Tyr‑705. Finally, it was found that PGV‑1 and CCA‑1.1 but not PGV‑1, significantly attenuates the growth of OS developed on the chicken egg chorioallantoic membrane (CAM). Collectively, the present results strongly suggest that curcumin analog‑mediated targeting of p300 might provide a clue to develop an effective treatment strategy against patients with OS. |
| 巻・号 | 53(4) |
| 公開日 | 2025-4-1 |
| DOI | 10.3892/or.2025.8880 |
| PII | 47 |
| PMID | 39981920 |
| MeSH | Acetylation / drug effects Animals Antineoplastic Agents* / pharmacology Apoptosis / drug effects Bone Neoplasms* / drug therapy Bone Neoplasms* / metabolism Bone Neoplasms* / pathology Cell Line, Tumor Cell Proliferation / drug effects Chick Embryo Curcumin* / analogs & derivatives Curcumin* / pharmacology E1A-Associated p300 Protein* / antagonists & inhibitors E1A-Associated p300 Protein* / metabolism Gene Expression Regulation, Neoplastic / drug effects Histones* / metabolism Humans Molecular Docking Simulation Osteosarcoma* / drug therapy Osteosarcoma* / metabolism Osteosarcoma* / pathology STAT3 Transcription Factor / metabolism p300-CBP Transcription Factors* / antagonists & inhibitors p300-CBP Transcription Factors* / metabolism |
| IF | 3.417 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MG-63(RCB1890) Saos-2 |