論文 - 詳細
| RRC ID | 86034 |
|---|---|
| 著者 | Muramoto J, Sakamoto T. |
| タイトル | Tripodal Quinone-Cyanine G-Quadruplex Ligands as Novel Photosensitizers on Photoinduced Cancer Cell Death. |
| ジャーナル | Molecules |
| Abstract |
Guanine-quadruplex (G4) selective photosensitizers have huge potential for photodynamic therapy against various diseases correlated with G4 DNA and G4 RNAs; however, the types of photosensitizer skeletons available are limited. Herein, we investigated the ability of our original G4 ligands, tripodal quinone-cyanine dyes (tpQCy(s)), which were developed as fluorescent probes for G4, to act as photosensitizers for cancer-selective apoptosis inducers. The results indicated that the tpQCy skeleton has great potential for developing G4-targeted cancer-selective photosensitizers for photodynamic therapy. Among the two tpQCys, only QCy(BnBT)3, which has greater G4 selectivity, exhibited photoinduced cytotoxicity in HeLa cell growth, suggesting that the direct oxidation of G4 DNA or RNA is crucial for photoinduced cytotoxicity. RNA-seq analysis using a next-generation sequencing technique revealed that apoptosis was clearly induced by photoirradiation after QCy(BnBT)3 treatment. |
| 巻・号 | 29(21) |
| 公開日 | 2024-10-28 |
| DOI | 10.3390/molecules29215094 |
| PII | molecules29215094 |
| PMID | 39519736 |
| PMC | PMC11547667 |
| MeSH | Apoptosis* / drug effects Benzoquinones Carbocyanines / chemistry Carbocyanines / pharmacology G-Quadruplexes* / drug effects HeLa Cells Humans Ligands Neoplasms / drug therapy Neoplasms / pathology Photochemotherapy* / methods Photosensitizing Agents* / chemical synthesis Photosensitizing Agents* / chemistry Photosensitizing Agents* / pharmacology Quinones / chemistry Quinones / pharmacology |
| IF | 3.267 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa(RCB0007) |