Reference - Detail
| RRC ID | 86291 |
|---|---|
| Author | Shun Li JS, Liu Y, Kim AR, Qadiri M, Xu J, Xia B, Binari R, Asara JM, Hu Y, Perrimon N. |
| Title | The epigenetic factor Zrf1 regulates intestinal stem cell proliferation during midgut regeneration. |
| Journal | PLoS Genet |
| Abstract |
Stem cells are essential for tissue maintenance and regeneration, balancing self-renewal and differentiation to support homeostasis and repair. Through an RNAi screen in the Drosophila midgut, we identified the epigenetic factor Zrf1 as a critical regulator of intestinal stem cell (ISC) proliferation. Functional analyses reveal that Zrf1 integrates inputs from multiple signaling pathways and interacts with components of the RNA-induced silencing complex (RISC). Our findings suggest that Zrf1 is potentially a key chromatin regulator necessary for maintaining stem cell proliferation, enhancing our understanding of the molecular controls underlying stem cell function and chromatin-associated defects. |
| Volume | 21(10) |
| Pages | e1011910 |
| Published | 2025-10-1 |
| DOI | 10.1371/journal.pgen.1011910 |
| PII | PGENETICS-D-25-00114 |
| PMID | 41144510 |
| PMC | PMC12574921 |
| MeSH | Animals Cell Differentiation / genetics Cell Proliferation / genetics Chromatin / genetics Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / genetics Epigenesis, Genetic Intestines* / cytology Intestines* / physiology RNA Interference Regeneration* / genetics Signal Transduction / genetics Stem Cells* / cytology Stem Cells* / metabolism |
| IF | 5.175 |
| Resource | |
| Drosophila | 10565R-1 |