論文 - 詳細
| RRC ID | 86454 |
|---|---|
| 著者 | Raimondo MG, Mohammadian H, Angeli MR, Alivernini S, Fedorchenko V, Huang K, Demmler R, Rhein P, Xu C, Li YN, Micheroli R, Winter Z, Rigau AR, Anchang CG, Soare A, Luber M, Labinsky H, Chang J, Günther C, Fearon U, Veale DJ, Ciccia F, Rech J, Sticherling M, Bäuerle T, Distler JHW, Kurowska-Stolarska MS, Mack M, Ekici AB, Croft AP, Distler O, Maric HM, Ospelt C, Cañete JD, D'Agostino MA, Schett G, Rauber S, Ramming A. |
| タイトル | Skin-derived myeloid precursors and joint-resident fibroblasts spread psoriatic disease from skin to joints. |
| ジャーナル | Nat Immunol |
| Abstract |
Psoriatic disease initially affects the skin and later extends to the joints. Here, we show a two-step process that orchestrates the spread of inflammation from the skin to the joints. Induction of psoriatic skin disease in photoconvertible mice, followed by sequencing and computational characterization of skin-derived cells in the joints, was used to identify a population of CD2+MHC-II+CCR2+ myeloid precursors that builds a skin-derived myeloid cell compartment in the joints. Single-cell cross-species reference mapping and mitochondrial variant tracing showed an orthologous human cell population. Interactome analysis of the joints showed that in a second step, resident regulatory CD200+ fibroblasts regulate the priming of CD2+MHC-II+CCR2+ myeloid precursors, which subsequently control IL-17 expression in T cells. Hence, the spread of inflammation requires a distinct migratory myeloid precursor population and a permissive local tissue environment, similar to tumor metastasis. |
| 巻・号 | 27(1) |
| ページ | 35-47 |
| 公開日 | 2026-1-1 |
| DOI | 10.1038/s41590-025-02351-z |
| PII | 10.1038/s41590-025-02351-z |
| PMID | 41482544 |
| PMC | PMC12764428 |
| MeSH | Animals Cell Movement Disease Models, Animal Fibroblasts* / immunology Fibroblasts* / metabolism Fibroblasts* / pathology Humans Interleukin-17 / metabolism Joints* / immunology Joints* / pathology Mice Myeloid Cells Myeloid Progenitor Cells* / immunology Myeloid Progenitor Cells* / metabolism Psoriasis* / immunology Psoriasis* / pathology Skin* / immunology Skin* / pathology T-Lymphocytes / immunology |
| IF | 20.479 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 37 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 104.6 |
| リソース情報 | |
| 実験動物マウス | RBRC09257 RBRC05737 |