Reference - Detail
|Author||Takeda O, Takechi S, Katoh T, Yamaguchi T.|
|Title||The Role of dihydropyrazines in accelerated death of Escherichia coli on addition of copper(II).|
|Journal||Biol Pharm Bull|
Dihydropyrazines (DHPs), which are derived from sugars, inhibit the growth of Escherichia coli. Addition of copper(II) ion (Cu2+) accelerates the effect of DHPs, resulting in cell death. Investigation of the lethal effect in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains and radical scavengers suggested that the cytotoxic and genotoxic damage was caused by radical species (hydroxyl, superoxide anion, and carbon-centered radicals) generated from reaction of DHPs with Cu2+.
|MeSH||Copper / pharmacology* Drug Synergism Escherichia coli / drug effects* Pyrazines / pharmacology*|
|WOS Category||PHARMACOLOGY & PHARMACY|
|Prokaryotes E. coli||ME8079(AB1157) ME8087(AB2463) ME8303(UM197) ME8299(UM119) ME8993(QC774)|