RRC ID 865
Author Takeda O, Takechi S, Katoh T, Yamaguchi T.
Title The Role of dihydropyrazines in accelerated death of Escherichia coli on addition of copper(II).
Journal Biol Pharm Bull
Abstract Dihydropyrazines (DHPs), which are derived from sugars, inhibit the growth of Escherichia coli. Addition of copper(II) ion (Cu2+) accelerates the effect of DHPs, resulting in cell death. Investigation of the lethal effect in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains and radical scavengers suggested that the cytotoxic and genotoxic damage was caused by radical species (hydroxyl, superoxide anion, and carbon-centered radicals) generated from reaction of DHPs with Cu2+.
Volume 28(7)
Pages 1161-4
Published 2005-7-1
DOI 10.1248/bpb.28.1161
PII JST.JSTAGE/bpb/28.1161
PMID 15997090
MeSH Copper / pharmacology* Drug Synergism Escherichia coli / drug effects* Pyrazines / pharmacology*
IF 1.54
Times Cited 16
Prokaryotes E. coli ME8079(AB1157) ME8087(AB2463) ME8303(UM197) ME8299(UM119) ME8993(QC774)