Reference - Detail
| RRC ID | 86704 |
|---|---|
| Author | El Yakoubi W, Pan B, Akera T. |
| Title | Hybrid female sterility due to cohesin protection errors in mouse oocytes. |
| Journal | Sci Adv |
| Abstract |
Hybrid incompatibility can lead to lethality and sterility of F1 hybrids, promoting speciation. The cell biological basis underlying hybrid incompatibility remains largely unknown, especially in mammals. Here, we found that female hybrids between Mus musculus domesticus and Mus spicilegus mice are sterile due to the failure of homologous-chromosome separation in oocyte meiosis, producing aneuploid eggs. This nondisjunction phenotype was driven by the mislocalization of the cohesin protector, SGO2, along the chromosome arms instead of its typical centromeric enrichment, resulting in cohesin overprotection. The upstream kinase, BUB1, showed a higher activity in hybrid oocytes, explaining SGO2 mistargeting. Higher BUB1 activity was not observed in mitosis, consistent with viable hybrid mice. Cohesion defects were also evident in hybrid mice from another genus, Peromyscus, wherein cohesin protection is weakened. Defective cohesion in oocytes is a leading cause of reduced fertility. Our work provides evidence that a major cause of human infertility may play a positive role in mammalian speciation. |
| Volume | 12(6) |
| Pages | eadx9729 |
| Published | 2026-2-6 |
| DOI | 10.1126/sciadv.adx9729 |
| PMID | 41637509 |
| PMC | PMC12871464 |
| MeSH | Animals Cell Cycle Proteins* / genetics Cell Cycle Proteins* / metabolism Chromosomal Proteins, Non-Histone* / genetics Chromosomal Proteins, Non-Histone* / metabolism Cohesins Female Hybridization, Genetic* Infertility, Female* / genetics Infertility, Female* / metabolism Meiosis / genetics Mice Oocytes* / metabolism Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism |
| IF | 13.117 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 43 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC00661 |