| RRC ID |
86720
|
| 著者 |
Préau L, Lischke A, Merkel M, Oegel N, Weissenbruch M, Michael A, Park H, Gradl D, Kupatt C, le Noble F.
|
| タイトル |
Parenchymal cues define Vegfa-driven venous angiogenesis by activating a sprouting competent venous endothelial subtype.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Formation of organo-typical vascular networks requires cross-talk between differentiating parenchymal cells and developing blood vessels. Here we identify a Vegfa driven venous sprouting process involving parenchymal to vein cross-talk regulating venous endothelial Vegfa signaling strength and subsequent formation of a specialized angiogenic cell, prefabricated with an intact lumen and pericyte coverage, termed L-Tip cell. L-Tip cell selection in the venous domain requires genetic interaction between vascular Aplnra and Kdrl in a subset of venous endothelial cells and exposure to parenchymal derived Vegfa and Apelin. Parenchymal Esm1 controls the spatial positioning of venous sprouting by fine-tuning local Vegfa availability. These findings may provide a conceptual framework for understanding how Vegfa generates organo-typical vascular networks based on the selection of competent endothelial cells, induced via spatio-temporal control of endothelial Kdrl signaling strength involving multiple parenchymal derived cues generated in a tissue dependent metabolic context.
|
| 巻・号 |
15(1)
|
| ページ |
3118
|
| 公開日 |
2024-4-10
|
| DOI |
10.1038/s41467-024-47434-x
|
| PII |
10.1038/s41467-024-47434-x
|
| PMID |
38600061
|
| PMC |
PMC11006894
|
| MeSH |
Angiogenesis*
Endothelial Cells* / metabolism
Neovascularization, Physiologic* / genetics
Veins
|
| IF |
12.121
|
| リソース情報 |
| ゼブラフィッシュ |
UAS:GFP |
