論文 - 詳細
| RRC ID | 86744 |
|---|---|
| 著者 | Kawamura K, Ono K, Mishima E, Hashizume O, Conrad M, Miki H, Funato Y. |
| タイトル | Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death. |
| ジャーナル | Cell Rep |
| Abstract |
Mg2+ is an essential cofactor for numerous enzymes, supporting fundamental cellular processes. The phosphatase of regenerating liver (PRL) protein family, frequently upregulated in cancer, inhibits cyclin M (CNNM) Mg2+ efflux transporters. To elucidate the physiological role of PRL in Mg2+ homeostasis at the cellular level, we employed combined genetic knockout and knockdown approaches. PRL deletion led to marked reduction of intracellular Mg2+ levels and triggered extensive cell death. Transcriptomic analysis revealed activation of the NF-κB pathway, and, accordingly, the genetic deletion of NF-κB p65 subunit abrogated cell death. Similarly, CNNM overexpression triggered intracellular Mg2+ decrease, NF-κB activation, and subsequent cell death. Notably, this form of cell death exhibited characteristic morphological features, including actin-driven fiber-like protrusions, distinguishing it from known cell death modalities. Our findings uncover a distinct mode of NF-κB-dependent cell death triggered by intracellular Mg2+ decrease. |
| 巻・号 | 45(2) |
| ページ | 116964 |
| 公開日 | 2026-2-10 |
| DOI | 10.1016/j.celrep.2026.116964 |
| PII | S2211-1247(26)00042-2 |
| PMID | 41671091 |
| MeSH | Animals Cell Death Humans Magnesium* / metabolism Mice NF-kappa B* / metabolism Signal Transduction Transcription Factor RelA / metabolism |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 1.7 |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) |
| 遺伝子材料 | pCAG-HIVgp (RDB04394) pCMV-VSV-G-RSV-Rev (RDB04393) |