論文 - 詳細
| RRC ID | 86745 |
|---|---|
| 著者 | Akimoto Y, Katsube A, Miyamae Y, Shigemori H. |
| タイトル | Induction of Hepatocyte Growth Factor Production by Quercetin. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
Hepatocyte growth factor (HGF) exhibits mitogenic, motogenic, and morphogenic activities. Enhancing HGF production could serve as a therapeutic approach for organ regeneration, wound healing, and embryogenesis. Notably, HGF demonstrates therapeutic potential in the treatment of neurodegenerative diseases. In this study, we found that quercetin promotes HGF production in normal human dermal fibroblasts (NHDF) at low concentrations. cAMP response element binding protein (CREB), a transcription factor, is phosphorylated. Additionally, this activity may result from quercetin's interaction with the β2 adrenaline receptor (β2AR). Further pharmacological analysis suggested that HGF production is promoted via PKA pathway. In conclusion, quercetin shows potential as a drug for treating organ-related diseases, including neurodegenerative disorders, by enhancing HGF production. |
| 巻・号 | 49(2) |
| ページ | 249-253 |
| 公開日 | 2026-1-1 |
| DOI | 10.1248/bpb.b25-00196 |
| PMID | 41656086 |
| MeSH | Cells, Cultured Cyclic AMP Response Element-Binding Protein / metabolism Cyclic AMP-Dependent Protein Kinases / metabolism Fibroblasts* / drug effects Fibroblasts* / metabolism Hepatocyte Growth Factor* / biosynthesis Hepatocyte Growth Factor* / metabolism Humans Phosphorylation Quercetin* / pharmacology Receptors, Adrenergic, beta-2 / metabolism |
| IF | 1.863 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) |