論文 - 詳細
| RRC ID | 86835 |
|---|---|
| 著者 | Kodama-Maruyama Y, Tsurushima H, Koga A, Nagai-Yoshioka Y, Yamasaki R, Habu M, Yoshioka I, Ariyoshi W. |
| タイトル | Molecular Basis of Surfactin-Induced Macrophage Modulation and Its Implications in Medication-Related Osteonecrosis of the Jaw Pathogenesis. |
| ジャーナル | Int J Mol Sci |
| Abstract |
Medication-related osteonecrosis of the jaw (MRONJ) is a refractory disease for which no established treatment currently exists. Surfactin, a biosurfactant produced by Bacillus subtilis, exhibits antimicrobial activity, anticancer effects, and anti-inflammatory properties, suggesting its potential medical applications. This study aimed to elucidate the ability of surfactin to modulate the immune response induced by lipopolysaccharide (LPS) derived from periodontal pathogens (Aggregatibacter actinomycetemcomitans), clarify the underlying molecular mechanisms, and explore its potential utility in the treatment of MRONJ. Reverse transcription quantitative polymerase chain reaction demonstrated that surfactin suppresses LPS-induced interleukin-6 (IL-6) expression and secretion in J774.1 cells in a concentration-dependent manner. Western blot analysis showed that surfactin inhibited activation of the JNK-c-Jun-AP-1 axis and the JAK/STAT signaling pathways in J774.1 cells. The effects of surfactin administration were further evaluated in an in vivo MRONJ model. Co-treatment with surfactin significantly reduced the extent of LPS-induced bone necrosis. Overall, these findings suggest that surfactin suppresses LPS-induced IL-6 expression in macrophages and inhibits osteonecrosis induced by bisphosphonate preparations and LPS through negative regulation of the JNK-c-Jun-AP-1 axis and inhibition of the JAK/STAT pathway. Hence, surfactin may represent a promising candidate for MRONJ management. |
| 巻・号 | 27(3) |
| 公開日 | 2026-1-23 |
| DOI | 10.3390/ijms27031157 |
| PII | ijms27031157 |
| PMID | 41683585 |
| PMC | PMC12897720 |
| MeSH | Aggregatibacter actinomycetemcomitans Animals Bisphosphonate-Associated Osteonecrosis of the Jaw* / drug therapy Bisphosphonate-Associated Osteonecrosis of the Jaw* / metabolism Bisphosphonate-Associated Osteonecrosis of the Jaw* / pathology Cell Line Interleukin-6 / genetics Interleukin-6 / metabolism Lipopeptides* / pharmacology Lipopolysaccharides Macrophages* / drug effects Macrophages* / immunology Macrophages* / metabolism Male Mice Peptides, Cyclic* / pharmacology Signal Transduction / drug effects |
| IF | 4.556 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) RAW 264(RCB0535) |