Reference - Detail
| RRC ID | 86844 |
|---|---|
| Author | Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H. |
| Title | ASK1 signalling regulates brown and beige adipocyte function. |
| Journal | Nat Commun |
| Abstract |
Recent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function. In brown or white adipocytes, the PKA-ASK1-p38 axis is activated in response to cAMP signalling and contributes to the cell-autonomous induction of genes, including Ucp1. Global and fat-specific ASK1 deficiency leads to impaired metabolic responses, including thermogenesis and oxygen consumption, at the cell and whole-body levels, respectively. Our data thus indicate that the ASK1 signalling axis is a regulator of brown and beige adipocyte gene expression and function. |
| Volume | 7 |
| Pages | 11158 |
| Published | 2016-4-5 |
| DOI | 10.1038/ncomms11158 |
| PII | ncomms11158 |
| PMID | 27045525 |
| PMC | PMC4822029 |
| MeSH | 3T3-L1 Cells Adipocytes, Brown / cytology Adipocytes, Brown / metabolism* Adipocytes, White / cytology Adipocytes, White / metabolism Adipose Tissue, Brown / cytology Adipose Tissue, Brown / metabolism* Adipose Tissue, White / cytology Adipose Tissue, White / metabolism Animals Cell Differentiation Cyclic AMP / metabolism Cyclic AMP-Dependent Protein Kinases / genetics Cyclic AMP-Dependent Protein Kinases / metabolism Female Gene Expression Regulation HEK293 Cells Humans Ion Channels / genetics Ion Channels / metabolism MAP Kinase Kinase Kinase 5 / genetics MAP Kinase Kinase Kinase 5 / metabolism* Male Mice Mice, Inbred C57BL Mitochondrial Proteins / genetics Mitochondrial Proteins / metabolism Oxygen Consumption / genetics Signal Transduction* Thermogenesis / genetics* Uncoupling Protein 1 p38 Mitogen-Activated Protein Kinases / genetics p38 Mitogen-Activated Protein Kinases / metabolism |
| IF | 12.121 |
| Resource | |
| Mice | RBRC01834 |