| RRC ID |
86850
|
| 著者 |
Taura F, Iijima M, Kurosaki F.
|
| タイトル |
Daurichromenic acid and grifolic acid: Phytotoxic meroterpenoids that induce cell death in cell culture of their producer Rhododendron dauricum.
|
| ジャーナル |
Plant Signal Behav
|
| Abstract |
Daurichromenic acid (DCA) is a meroterpenoid with anti-HIV activities that is isolated from Rhododendron dauricum L. We recently reported that DCA is biosynthesized and accumulated in the apoplast of glandular scales attached on the surface of young leaves of R. dauricum. In the present study, we confirmed that a cell suspension culture of R. dauricum could not produce DCA and its precursor grifolic acid even after elicitation with methyl jasmonate and β-cyclodextrin. In addition, exogenous supplementation of DCA and grifolic acid effectively induced cell death in the same culture, with apoptosis-associated phenomena such as cytoplasmic shrinkage, chromatin condensation, and genomic DNA degradation. These findings suggested that DCA and grifolic acid are phytotoxic metabolites that have to be sequestered in the apoplast to avoid self-poisoning.
|
| 巻・号 |
13(1)
|
| ページ |
e1422463
|
| 公開日 |
2018-1-2
|
| DOI |
10.1080/15592324.2017.1422463
|
| PMID |
29286881
|
| PMC |
PMC5790407
|
| MeSH |
Cell Death / drug effects
Cells, Cultured
Chromans / chemistry
Chromans / pharmacology*
Rhododendron / cytology*
Sesterterpenes / chemistry
Sesterterpenes / pharmacology*
|
| IF |
1.671
|
| リソース情報 |
| シロイヌナズナ / 植物培養細胞・遺伝子 |
rpc00001 |
