| RRC ID |
86861
|
| Author |
Uegaki R, Maega S, Ono M, Bito T, Iwasaki T, Shiraishi A, Satake H, Kawano T.
|
| Title |
The FMRFamide-like peptide FLP-11 regulates the production and secretion of the TGF-β-like protein DAF-7 during Caenorhabditis elegans larval development.
|
| Journal |
Sci Rep
|
| Abstract |
FMRFamide-like peptides (FLPs) are widely conserved in nematodes. Here, we conducted a molecular genetic study to confirm that the flp-11 gene regulates larval development in the free-living soil nematode model species Caenorhabditis elegans. We demonstrated that: (1) FLP-11 suppresses larval development, resulting in dauer diapause; (2) the production and secretion of FLP-11 by specific neurons is modulated by the availability of food (e.g., Escherichia coli) and by population density, both of which determine larval development/dauer diapause via transforming growth factor-β (TGF-β)-like and insulin-like signaling; (3) the FLP-11 peptide reduces the production and secretion of DAF-7, the sole TGF-β-like protein involved in larval development; (4) FLP-11 is not involved in insulin-like signaling; (5) FLP-11 modulates dauer diapause via neuropeptide receptor-22 (NPR-22), which regulates DAF-7 production and secretion. This study highlights the significance of a short neuropeptide that responds to the growth environment and directly regulates a TGF-β-like protein via its receptor candidate, thereby influencing larval development in C. elegans.
|
| Volume |
16(1)
|
| Pages |
4634
|
| Published |
2026-1-7
|
| DOI |
10.1038/s41598-025-34917-0
|
| PII |
10.1038/s41598-025-34917-0
|
| PMID |
41501349
|
| PMC |
PMC12867994
|
| MeSH |
Animals
Caenorhabditis elegans* / genetics
Caenorhabditis elegans* / growth & development
Caenorhabditis elegans* / metabolism
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Diapause
FMRFamide* / metabolism
Gene Expression Regulation, Developmental
Larva / genetics
Larva / growth & development
Larva / metabolism
Neurons / metabolism
Neuropeptides / metabolism
Receptors, Neuropeptide / metabolism
Signal Transduction
Transforming Growth Factor beta* / metabolism
|
| Resource |
| C.elegans |
tm2706 |
