論文 - 詳細
| RRC ID | 86873 |
|---|---|
| 著者 | Dong Z, Lu Y, Fang G, Zhang Q, Sheng Y, Pang L, Chen J, Shi W, Feng T, Zhang J, Zhang Y, Li G, Chen X, Huang J, Zhan S. |
| タイトル | A rare, evolutionarily conserved venom protein benefits endoparasitism across parasitoids. |
| ジャーナル | Cell Genom |
| Abstract |
Although many venom proteins and other parasitic effectors have been identified in various specific systems of parasitoids, key elements that contribute to parasitic success across a broad range of taxa remain largely unexplored. Here, we focus on Leptopilina and conduct a large-scale, multi-omics study to explore common venom proteins for these drosophilid parasitoids. We find that this genus has undergone extensive chromosome rearrangements and a rapid turnover of venom gene repertoires between species. Interestingly, we identified a lineage-specific venom lipase, Leptopilina-specific venom lipase (LVL), as a rare venom protein that is subject to evolutionary constraint and recruited by all Leptopilina species. Functional genetics studies on LVL reveal its critical role in hydrolyzing host lipids under acidic conditions, which in turn ensures the nutrition supply for the embryonic development of parasitoids. Our study provides a paradigm to characterize adaptive effectors across diverse insects and highlights the importance of host lipid utilization in the parasitization of parasitoids. |
| 巻・号 | 5(8) |
| ページ | 100920 |
| 公開日 | 2025-8-13 |
| DOI | 10.1016/j.xgen.2025.100920 |
| PII | S2666-979X(25)00176-4 |
| PMID | 40541180 |
| PMC | PMC12366661 |
| MeSH | Animals Evolution, Molecular Host-Parasite Interactions Insect Proteins* / genetics Insect Proteins* / metabolism Lipase* / genetics Lipase* / metabolism Phylogeny Wasp Venoms* / genetics Wasp Venoms* / metabolism Wasps / genetics |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | k-s02 |