Reference - Detail
| RRC ID | 86955 |
|---|---|
| Author | Biggs LC, Mäkelä OJ, Myllymäki SM, Das Roy R, Närhi K, Pispa J, Mustonen T, Mikkola ML. |
| Title | Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation. |
| Journal | Elife |
| Abstract |
Mesenchymal condensation is a critical step in organogenesis, yet the underlying molecular and cellular mechanisms remain poorly understood. The hair follicle dermal condensate is the precursor to the permanent mesenchymal unit of the hair follicle, the dermal papilla, which regulates hair cycling throughout life and bears hair inductive potential. Dermal condensate morphogenesis depends on epithelial Fibroblast Growth Factor 20 (Fgf20). Here, we combine mouse models with 3D and 4D microscopy to demonstrate that dermal condensates form de novo and via directional migration. We identify cell cycle exit and cell shape changes as early hallmarks of dermal condensate morphogenesis and find that Fgf20 primes these cellular behaviors and enhances cell motility and condensation. RNAseq profiling of immediate Fgf20 targets revealed induction of a subset of dermal condensate marker genes. Collectively, these data indicate that dermal condensation occurs via directed cell movement and that Fgf20 orchestrates the early cellular and molecular events. |
| Volume | 7 |
| Published | 2018-7-31 |
| DOI | 10.7554/eLife.36468 |
| PII | 36468 |
| PMID | 30063206 |
| PMC | PMC6107334 |
| MeSH | Actins / metabolism Animals Cell Aggregation Cell Cycle* Cell Lineage Cell Movement* Cell Shape Dermis / cytology* Dermis / ultrastructure Fibroblast Growth Factor 9 / pharmacology Fibroblast Growth Factors / metabolism* Fibroblasts / cytology Fibroblasts / metabolism Hair Follicle / cytology* Mice, Inbred C57BL Morphogenesis Receptors, Fibroblast Growth Factor / metabolism Receptors, Vascular Endothelial Growth Factor / metabolism SOXB1 Transcription Factors / metabolism Signal Transduction Transcription, Genetic |
| IF | 7.08 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | News |
| Total number of mentions | 20 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC02892 |