論文 - 詳細
| RRC ID | 86977 |
|---|---|
| 著者 | Takeo M, Toyoshima KE, Fujimoto R, Iga T, Takase M, Ogawa M, Tsuji T. |
| タイトル | Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair. |
| ジャーナル | Nat Commun |
| Abstract |
Biological rhythms are involved in almost all types of biological processes, not only physiological processes but also morphogenesis. Currently, how periodic morphological patterns of tissues/organs in multicellular organisms form is not fully understood. Here, using mouse zigzag hair, which has 3 bends, we found that a change in the combination of hair progenitors and their micro-niche and subsequent bend formation occur every three days. Chimeric loss-of-function and gain-of-function of Ptn and Aff3, which are upregulated immediately before bend formation, resulted in defects in the downward movement of the micro-niche and the rhythm of bend formation in an in vivo hair reconstitution assay. Our study demonstrates the periodic change in the combination between progenitors and micro-niche, which is vital for the unique infradian rhythm. |
| 巻・号 | 14(1) |
| ページ | 4478 |
| 公開日 | 2023-8-4 |
| DOI | 10.1038/s41467-023-39605-z |
| PII | 10.1038/s41467-023-39605-z |
| PMID | 37542032 |
| PMC | PMC10403492 |
| MeSH | Animals Hair Hair Follicle Infradian Rhythm* Mice Periodicity |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 15 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02707 |